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In What Ways Should PAH (arterial) And PVH (venous) Be Treated Differently?

A myPHteam Member asked a question 💭
East Greenwich, RI

I have read that certain medications meant for one type could actually be harmful if used for the other. Apparently two of my pulmonary doctors have not reached consensus on which of those 2 types of PH I have, leading me to fear bein prescribed the wrong medication.

August 5, 2023
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A myPHteam Member

I'm sharing a few links with you that you might find useful. Basically, it comes down to the pulmonary wedge pressure (calculated during a right heart cath).

"Pulmonary hypertension (PH) is defined by a mean pulmonary artery pressure (mPAP) ≥25 mm Hg. 1 Pulmonary arterial hypertension (PAH), group 1 in the Dana Point Classification, requires a pulmonary wedge pressure (PWP) ≤15 mm Hg. 2, 3 Group 2, pulmonary venous hypertension (PVH), is defined by a PWP >15 mm Hg in addition to an elevated mPAP, and results from elevation in postcapillary pressure attributable to left ventricular (LV) systolic or diastolic dysfunction or left heart valvular disease."

https://www.myphteam.com/resources/pulmonary-ve...

https://www.ahajournals.org/doi/full/10.1161/CI...

https://pulmonaryhypertensionnews.com/pulmonary....

August 5, 2023
A myPHteam Member

Good question. I actually have 3, b/c I spend a few mo yhs in Florida each winter. When I was diagnosed by the first, where I live in RI, he told me that your standard all-purpose pulmonologist is not fully trained in PH, since it is rare and there are so many standard respiratory disorders. He said I need someone who deals ONLY in PH. I was astonished not to find one near me in FL, where there are so many specialists. Lo and behold, a Boston specialist has an office also in East Providence, RI, only a half hour's drive away. I figure I need all the help I can get! I am struck by how many in our PH group say that their pulmonoligists seem to take a wait-and-see approach, or seem reluctant to prescribe meds. It seems to confirm that there's a lot still to learn about this disease, and that we all need to advocate for ourselves!!

August 13, 2023
A myPHteam Member

@A myPHteam Member I so agree. There is so much to be learned about this disease. I'm fortunate. My pulmonologist is a PH specialist. My cardiologist readily admitted he is not qualified to manage PAH. I'm also baffled by the "wait and see" philosophy of some physicians. Within a week of diagnosis, I started my first PAH medication. My physician advised treating PAH as aggressively as possible as long as I could tolerate the medications.

August 13, 2023
A myPHteam Member

I see a cardiologist who specializes in PAH. I recommend finding one near you. My regular cardiologist recommended one. He is great. My pulmonologist didn't even diagnose me.

August 5, 2023
A myPHteam Member

Treatments for Pulmonary Arterial Hypertension (PAH) and Pulmonary Venous Hypertension (PVH) differ significantly due to their distinct underlying causes:

Treating PAH
- Medications:
- Phosphodiesterase 5 inhibitors (e.g., sildenafil) act as vasodilators to open up blood vessels.
- Endothelin receptor antagonists Show Full Answer

Treatments for Pulmonary Arterial Hypertension (PAH) and Pulmonary Venous Hypertension (PVH) differ significantly due to their distinct underlying causes:

Treating PAH:
- Medications:
- Phosphodiesterase 5 inhibitors (e.g., sildenafil) act as vasodilators to open up blood vessels.
- Endothelin receptor antagonists prevent blood vessels from constricting.
- Surgery:
- For chronic thromboembolic pulmonary hypertension (CTEPH), surgeries to remove blockages or expand arteries using balloon catheters.
- Severe Cases:
- Lung transplant may be required.

Treating PVH:
- Medications:
- Diuretics to address fluid retention.
- Angiotensin-converting enzyme inhibitors, Angiotensin II receptor blockers, and Beta-blockers to control blood pressure and reduce heart workload.
- Surgery:
- For valve stenosis or narrowing, surgery to repair the valve may be beneficial.

Key Differences:
- PAH: Focuses on decreasing blood pressure in the lungs by opening pulmonary arteries.
- PVH: Focuses on managing left heart disease and fluid retention, with pulmonary vasodilators generally not recommended.

Accurate diagnosis is crucial as treatments for one condition can harm someone with the other.

July 30, 2024

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